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Publications of IMIDIA Members


Attali M, Stetsyuk V, Basmaciogullari A, Aiello V, Zanta-Boussif MA, Duvillie B, Scharfmann R. Control of Beta-Cell Differentiation by the Pancreatic Mesenchyme. Diabetes 2007, 56:1248-1258

Benzinou M, Creemers JW, Choquet H, Lobbens S, Dina C, Durand E, Guerardel A, Boutin P, Jouret B, Heude B, Balkau B, Tichet J, Marre M, Potoczna N, Horber F,Le Stunff C, Czernichow S, Sandbaek A, Lauritzen T, Borch-Johnsen K, Andersen G, Kiess W, Körner A, Kovacs P, Jacobson P, Carlsson LM, Walley AJ, Jørgensen T, Hansen T, Pedersen O, Meyre D, Froguel P. Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet. 2008 Aug; 40(8):943-5. Epub 2008 Jul 6

Bonal C, Thorel F, Ait-Lounis A, Reith W, Trumpp A, and Herrera PL: Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells into Adipocytes in Mice. GASTROENTEROLOGY, 2009, 136: 309-19

Bottlaender M, Valette H, Delforge J, Guenther I, Curet O, George P, Dollé F, and Grégoire M-C. In vivo quantification of monoamine oxidase-A in baboon brain: A PET study using [11C]befloxatone and the multi-injection approach. J. Cereb. Blood Flow Metab. 2010, 30 (4), 792-800

Bouatia-Naji N, Rocheleau G, Van Lommel L, Lemaire K, Schuit F, Cavalcanti-Proença C, Marchand M, Hartikainen AL, Sovio U, De Graeve F, Rung J, Vaxillaire M, Tichet J, Marre M, Balkau B, Weill J, Elliott P, Jarvelin MR, Meyre D, Polychronakos C, Dina C, Sladek R, Froguel P. A polymorphism within the G6PC2 gene is associated with fasting plasma glucose levels. Science. 2008 May 23; 320(5879):1085-8. Epub 2008 May 1

Bramoullé Y, Roeda D and Dollé F. A simplified [11C]phosgene synthesis. Tetrahedron Letters 2010, 51 (2), 313-316

Cabou C, Campistron G, Marsollier N, Leloup C, Cruciani-Guglielmacci C, Pénicaud L, Drucker DJ, Magnan C, Burcelin R. Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity. Diabetes. 2008 Oct;57(10):2577-87

Collombat P, Xu X, Ravassard P, Sosa-Pineda B, Dussaud S, Billestrup N, Madsen O, Serup P, Heimberg H, and Mansouri A. The misexpression of Pax4 in the mouse pancreas converts progenitor cells into alpha- and subsequently beta-cells. Cell. 2009 Aug 7;138(3):449-62

Desgraz R and Herrera PL: Pancreatic Neurogenin3-expressing cells are unipotent islet precursors. DEVELOPMENT, 2009, 136: 3567-3574

Dotta F, Censini S, van Halteren AG, Marselli L, Masini M, Dionisi S, Mosca F, Boggi U, Muda AO, Prato SD, Elliott JF, Covacci A, Rappuoli R, Roep BO, Marchetti P. Coxsackie B4 virus infection of beta cells and natural killer cell insulitis in recent-onset type 1 diabetic patients. Proc Natl Acad Sci U S A. 2007 104:5115-5120

Ehehalt F, Knoch KP, Erdmann K, Krautz C, Jäger M, Steffen A, Wegbrod C, Meisterfeld R, Kersting S, Bergert H, Kuhlisch E, Bornstein SR, Bonifacio E, Saeger HD, Solimena M. Impaired insulin turnover in islets from type 2 diabetic patients. Islets. 2010 Jan;2(1):30-6

Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J, Berthault MF, Magnan C, Cerasi E, Kaiser N, Leibowitz. mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes Diabetes. 2008 Apr;57(4):945-57

Grouwels G, Cai Y, Hoebeke I, Leuckx G, Heremans Y, Ziebold U, Stangé G, Chintinne M, Ling Z, Pipeleers D, Heimberg H and Van de Casteele M. Ectopic expression of E2F1 stimulates beta cell proliferation and function. Diabetes. 2010 (in press)

Guillemain G, Filhoulaud G, Da Silva-Xavier G, Rutter GA, Scharfmann R. Glucose is necessary for embryonic pancreatic endocrine cell differentiation J Biol Chem 282:15228 -37, 2007

Gurgul-Convey E, Lenzen S. Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells. J Biol Chem. 285:11121-11128, 2010

Hald, J., Sprinkel, A. E., Ray, M., Serup, P., Wright, C., Madsen, O.D.. (2008): Generation and Characterization of Ptf1a Antiserum and Localization of Ptf1a in relation to Nkx6.1 and Pdx1 during the earliest stages of Mouse Pancreas Development. J Histochem Cytochem 56(6): pp. 587-595

Haumaitre C, Lenoir O, Scharfmann R. Histone deacetylase inhibitors modify pancreatic cell fate determination and amplify endocrine progenitors. Mol Cell Biol. 2008;28:6373-6383

Kargar C, Ktorza A. Anatomical versus functional beta-cell mass in experimental diabetes. Diabetes Obes Metab. 2008, 10: 43-53

Klinck, R., Serup, P., Madsen, O.D., Jørgensen, M.C. (2008): Specificity of Four Monoclonal anti-Nkx6-1 Antibodies. J Histochem Cytochem 56(4): pp. 415-24

Klinger, S, Poussin, C, Debril, MB, Dolci, W, Halban, PA, Thorens, B. (2008) Increasing GLP-1-induced beta-cell proliferation by silencing the negative regulators of signaling CREMa and DUSP14. Diabetes 57, 584-593

Lemaire, K., Ravier, M.A., Chimienti, F., Rutter G.A., Gilon, P., Veld, P. Schuit, F. Insulin crystallisation depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice. Proc Natl Acad Sci, 106 (35): 14872-14877 (2009)

Lenzen, S: Oxidative stress: the vulnerable beta cell. Biochem Soc Trans 36, 343-347, 2008 (Review)

Lenzen, S: The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 51, 216-226, 2008 (Review)

Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL, Cnop M. The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia. 2007 50:2486-2494

Montet X, Pastor CM, Vallée JP, Becker CD, Geissbuhler A, Morel DR, Meda P. (2007) Improved visualization of vessels and hepatic tumors by micro-computed tomography (CT) using iodinated liposomes. Invest Radiol. 42, 652-658

Mziaut H, Kersting S, Knoch KP, Fan WH, Trajkovski M, Erdmann K, Bergert H, Ehehalt F, Saeger HD, Solimena M. ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs. Proc Natl Acad Sci U S A. 2008 Jan 15;105(2):674-9

Nicolson, T.J., Bellomo, E.A., Wijesekara, N., Loder, M.K., Baldwin, J.M., Gyulkhandanyan, A.V., Koshin, V., Tarasov, A.I., Carzaniga, R., Kronenberger, K., Taneja, T.K., da Silva Xavier, G., Libert, S., Froguel, P., Scharfmann, R., Stetsyuk, V., Ravassard, P., Parker, H., Gribble, F.M., Reimann, F., Sladek, R., Hughes, S.J., Johnson, P.R.V., Massebouef, M., Burcelin, R. Baldwin, S.A., Liu, M.m Lara-Lemus, R., Arvan, P., Schuit, F.C., Wheler, M.B., Chiemienti, F., Rutter, G.A.. Insulin storage and glucose homeostasis in mice null for the granuel zinc transporter ZnT8 and studies of the type 2 diabetes-associated varients Diabetes, 58(9):2070-83 (2009)

Pasquali, C, Bertschy-Meier, D, Chabert, C, Curchod, ML, Arod, C, Booth, R, Mechtler, K, Vilbois, F, Xenarios, I, Ferguson, CG, Prestwich, GD, Camps, M, Rommel, C.(2007) A chemical proteomics approach to phosphatidylinositol 3-kinase signaling in macrophages. Mol. Cell. Proteomics, 6(11):1829-41

Scharfmann, R., Xiao, X., Heimberg, H., Mallet, J., and Ravassard, P.. (2008). Beta cells within single human islets originate from multiple progenitors. PLoS ONE 3, e3559

Serre-Beinier V, Bosco D, Zulianello L, Charollais A, Caille D, Charpantier E, Gauthier BR, Diaferia GR, Giepmans BN, Lupi R, Marchetti P, Deng S, Buhler L, Berney T, Cirulli V, Meda P. (2008) Cx36 makes channels coupling human pancreatic β-cells, and correlates with insulin expression. Hum Mol Genet., Epub ahead of print

Sladek R, Rocheleau G, Rung J, Dina C, Shen L, Serre D, Boutin P, Vincent D, Belisle A, Hadjadj S, Balkau B, Heude B, Charpentier G, Hudson TJ, Montpetit A, Pshezhetsky AV, Prentki M, Posner BI, Balding DJ, Meyre D, Polychronakos C, Froguel P. A Genome-Wide Association Study Identifies Novel Risk Loci For Type 2 Diabetes. Nature. 2007 Feb 22;445(7130):881-5

Süss C, Czupalla C, Winter C, Pursche T, Knoch KP, Schroeder M, Hoflack B, Solimena M. Rapid changes of mRNA-binding protein levels following glucose and 3-isobutyl-1-methylxanthine stimulation of insulinoma INS-1 cells. Mol Cell Proteomics. 2009 Mar 8(3):393-408.

Taylor, CF, Paton, NW, Lilley, KS, Binz, PA, Julian, RK Jr, Jones, AR, Zhu, W, Apweiler, R, Aebersold, R, Deutsch, EW, Dunn, MJ, Heck, AJ, Leitner, A, Macht, M, Mann, M, Martens, L, Neubert, TA, Patterson, SD, Ping, P, Seymour, SL, Souda, P, Tsugita, A, Vandekerckhove, J, Vondriska, TM, Whitelegge, JP, Wilkins, MR, Xenarios, I, Yates, JR 3rd, Hermjakob, H. (2007) The minimum information about a proteomics experiment (MIAPE). Nature Biotechnol, 25(8):887-93

Thorel F, Népote V, Avril I, Kohno K, Desgraz R, Chera S, and Herrera PL: Conversion of adult pancreatic a-cells to b-cells after extreme b-cell loss. NATURE, 2010, 464: 1149-54

Valette H, Xiao Y, Peyronneau M-A, Damont A, Kozikowski A P, Wei Z-L, Kassiou M, Kellar K, Dollé F and Bottlaender M. [18F]ZW-104, a new radioligand for imaging neuronal nicotinic acetylcholine receptors - in vitro binding properties and PET studies in baboons. J. Nucl. Med. 2009, 50 (8), 1349-1355

Vinkenborg, J.L., Bellomo, E.A., Nicolson, T.J., Koay, M.S., Merkx, M., Rutter, G.A.. Accurate measurement of cytosolic free zinc concentration using eCALWY variants: a toolbox of genetically encoded FRET sensors. Nature Protocols , (2009)

Vinkenborg, J.L., Nicolson, T.J., Bellomo, E.A., Koay, M.S., Rutter, G.A.* Merkx, M. Genetically-encoded FRET sensors to monitor Zn2+ homeostasis in living cells. Nature Methods 6(10):737-40 (2009) *corresponding author

Xu X, D'Hoker J, Stangé G, Bonné S, De Leu N, Xiao X, Van de Casteele M, Mellitzer G, Ling Z, Pipeleers D, Bouwens L, Scharfmann R, Gradwohl G, Heimberg H. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell. 2008 Jan 25;132(2):197-207. (Featured Article)